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Agonist and antagonist play a key role in pharmacology and the human body by working against each other to establish a balance. When agonist is stimulating an action, the antagonist sits idle (Gordon, 2017). An agonist ties to the receptor site and causes the ion channel’s opening up to its full capacity and frequency, making the downstream signal transduction possible for utilization at the binding site. Compared to a full agonist, an additional receptor site allows the ion channel to open more frequently. Therefore, the agonist ties cause responses while the antagonist work against drugs by blocking the response (Staudt, et al., 2019). Agonist plays a role in binding and altering the receptors’ activity and functions while the antagonists help in biding receptors without altering its activities. The agonist, therefore, causes a response to the drug. Simultaneously, the antagonist works against the drug by blocking the response helping to cause stabilization in the receptor sites in resting phases, a mechanism similar to the lack of agonist at the receptor site (Staudt, et al., 2019).

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